Small assemblies of unmodified amyloid $beta;-protein are the proximate neurotoxin in Alzheimer?s disease
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چکیده
منابع مشابه
Small assemblies of unmodified amyloid beta-protein are the proximate neurotoxin in Alzheimer's disease.
Pioneering work in the 1950s by Christian Anfinsen on the folding of ribonuclease has shown that the primary structure of a protein "encodes" all of the information necessary for a nascent polypeptide to fold into its native, physiologically active, three-dimensional conformation (for his classic review, see [Science 181 (1973) 223]). In Alzheimer's disease (AD), the amyloid beta-protein (Abeta...
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Late compartments of amyloid precursor protein transport in SY5Y cells are involved in beta-amyloid secretion.
Amyloid plaques, composed mainly of the 39-43 amino acid betaA4 peptide, are a characteristic feature of Alzheimer's disease. Generation of betaA4 by proteolytic processing of the amyloid precursor protein (APP) is thought to occur in a pathway that includes the activity of two as yet unknown proteases, with beta-secretase cleaving at the N terminus and gamma-secretase releasing the C terminus ...
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ژورنال
عنوان ژورنال: Neurobiology of Aging
سال: 2004
ISSN: 0197-4580
DOI: 10.1016/s0197-4580(04)00089-2